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STX-001

A novel mRNA that triggers the expression of IL-12 in tumor cells.

Payload

IL-12

Route of Administration

INTRA-TUMORAL DELIVERY

Initial Clinical Development Plan

MELANOMA

TNBC/BREAST

HEAD & NECK CANCER

BLADDER

Two body scan images showing metastatic lesions at week 12 on the left image, with marked black spots, and a near-clear scan at week 30 on the right.

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STX-003

A systemically delivered mRNA that triggers the expression of IL-12 in tumor cells.

Payload

IL-12

Route of Administration

SYSTEMIC DELIVERY

Initial Clinical Development Plan

NSCLC

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STX-005

A systemically delivered circular mRNA that self-generates CAR-T cells.

Payload

CAR

Route of Administration

SYSTEMIC DELIVERY

Initial Clinical Development Plan

AUTOIMMUNE DISEASE

HEMATOLOGICAL MALIGNANCIES

Illustration showing a virus delivering genetic material into a cell, leading to production and display of antibodies on the cell surface.

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Best-in-Class Genetic Medicines with Plug-and-Play Delivery

Strand Signal Stack has produced a diverse pipeline of tissue-specific delivery platforms.

Solid Tumor Delivery Platform

Program

Modality

Indication

Payload

Discovery

Preclinical Development

IND-Enabling

Phase 1

Phase 2

STX-001

Self-replicating mRNA

Melanoma and Solid Tumors

IL-12

More Details

Program

Modality

Indication

Payload

Discovery

Preclinical Development

IND-Enabling

Phase 1

Phase 2

STX-003

Self-replicating mRNA circuit for intravenous delivery

NSCLC and Solid Tumors

IL-12

More Details

Program

Modality

Indication

Payload

Discovery

Preclinical Development

IND-Enabling

Phase 1

Phase 2

STX-005

Circular mRNA circuit for in vivo CAR T

Autoimmune Disease and Hematological Malignancies

CAR

More Details

Platform

Modality

Indication

Payload

STX-001

Self-replicating mRNA

Melanoma and Solid Tumors

IL-12

Discovery

Preclinical Development

IND-Enabling

Phase 1

Phase 2

More Details

Platform

Modality

Indication

Payload

STX-001

Self-replicating mRNA circuit for intravenous delivery

NSCLC and Solid Tumors

IL-12

Discovery

Preclinical Development

IND-Enabling

Phase 1

Phase 2

More Details

Platform

Modality

Indication

Payload

STX-001

Circular mRNA circuit for in vivo CAR T

Autoimmune Disease and Hematological Malignancies

CAR

Discovery

Preclinical Development

IND-Enabling

Phase 1

Phase 2

More Details

Solid Tumor Delivery Platform

Platform

Modality

Indication

Payload

Discovery

Preclinical Development

IND-Enabling

Phase 1

STX-001

Solid Tumor Delivery Platform

Self-replicating mRNA

Melanoma and solid tumors

IL-12

STX-003

Solid Tumor Delivery Platform

Self-replicating mRNA circuit for intravenous delivery (non-liver)

NSCLC and solid tumors

IL-12

STX-005

T Cell Delivery Platform

Circular RNA circuit for intravenous delivery (T cells)

Hematological malignancies

CAR

Partnerships

We Reach More Patients Faster by Working Together

Every biopharma company shouldn’t need to re-invent a delivery system for genetic medicine.

Together, we can use our infrastructure and innovations to deliver safe, effective genetic medicines to millions of new patients across indications and tissue targets.